This session focuses on the physiological mechanisms of skin in temperature regulation, including heat production, dissipation, and processes like vasodilation, vasoconstriction, sweating, and shivering. It highlights the role of skin structures such as sweat glands, blood vessels, and thermoreceptors, along with the influence of internal and external factors on maintaining temperature homeostasis. Clinically, this knowledge is vital for diagnosing and managing conditions like fever, heatstroke, hypothermia, and burns, as well as addressing thermoregulatory dysfunctions in hypothyroidism, diabetes, or autonomic neuropathy. Practical applications in routine practice include managing fever in infections, preventing heat-related illnesses in vulnerable populations, and assessing circulation in vascular disorders.