From the loss of self-tolerance to the precision of biologic therapies, this quiz explores the core principles and clinical spectrum of autoimmune disorders. Test your grasp on HLA associations, organ-specific versus systemic autoimmunity, and diagnostic markers like ANA and anti-dsDNA. Deepen your understanding of pathophysiology, immunologic mechanisms, and modern therapeutic strategies — essential for anyone aiming to master the art and science of immune-mediated disease management.