Learning Objectives: Bone Marrow and Hemopoiesis
Describe the anatomy and histology of bone marrow, including red and yellow marrow.
Identify the primary sites of active hematopoiesis in children and adults.
Define hemopoiesis and explain the differentiation of hematopoietic stem cells into myeloid and lymphoid lineages.
Recognize the role of growth factors (e.g., erythropoietin, thrombopoietin, colony-stimulating factors) in blood cell production.
Explain how bone marrow regulates the production of red blood cells, white blood cells, and platelets.
Interpret basic bone marrow findings and understand their clinical significance.
Discuss common disorders of hemopoiesis, including anemia, leukemia, and myeloproliferative conditions.
Apply knowledge of hemopoiesis in clinical reasoning, including interpretation of blood counts and relevance in treatment strategies like bone marrow transplantation.